Jordi | Journal of Oral DiagnosisOnline SubmissionReview an ArticleSOBEP - Sociedade Brasileira de Estomatologia e Patologia Oral
Volume 2 - 2017

Original Article

DOI: 10.5935/2525-5711.20170004

Surgical treatment of Schwannoma in lower lip: Case Report

Rafaela Savio Melzer; Vitor Hugo Candido Ferreira; Guilherme Klein Parise; Juliana Lucena Schussel; Laurindo Moacir Sassi

Hospital Erasto Gaertner

Corresponding authors: Hospital Erasto Gaertner
Rua Ovande do Amaral, 201, Jardim das Américas
Curitiba - PR. CEP 81520-060

Article received on February 28, 2017
Article accepted on March 21, 2017



INTRODUCTION: Of unknown aetiology, the schwannoma is a benign tumor that originates from the Schwann cells of the peripheral nerves. Around 25% to 45% of these tumors affect the head and neck region and are rare when affect the oral cavity. Presents itself as a lump of smooth surface, soft consistency and sessile. Histologically presents two standards, being the first known as Antoni A and the second, called Antoni B.
OBJECTIVE: To present a case of schwannoma in lower lip.
CASE REPORT: Male patient sought specialized care of a maxillofacial surgeon due to volume increase painless in lower lip. An incisional biopsy was performed and the diagnosis was of schwannoma. The lesion was removed in your entirety, the patient is well and no signs of recurrence.
CONCLUSION: The schwannomas occur infrequently in head and neck region, and it is rare when the lip is the site of involvement. The treatment of choice is surgical excision.

Keywords: Schwann Cells; Lip; Neurilemmoma



First described in 1910 with the nomenclature of Neurilemmoma, schwannoma, as it is also called, is a benign tumor that originates from the Schwann cells of the peripheral nerves1. Slow growing, this tumor is well encapsulated and can occur in any cranial nerve, which contains Schwann cells, except the olfactory nerves and optical are extensions of cerebral white matter2.

When the head and neck region, the schwannomas occur around 25% to 45%. Although your occurrence is rare in intraoral region, when it happens, tongue, palate and buccal floor are, respectively, the sites preferably3.

Although some authors consider the local trauma as cause of your injury, the aetiology remains unknown3,4. Commonly, the schwannoma demonstrates himself as a lump of smooth surface, soft consistency, sessile base, where growth is slow and the size can be variable4. The histopathological study of the lesion to be classified as two types, in which the cell pattern is organized in the form of Palisade is the kind Antoni A; While, in the second type, called Antoni B, cells are disorganized in a myxoid tissue5.

Just as in the histopathological finding, the schwannomas can be presented in two forms, namely: peripheral, in which the lesion is found in soft tissue and, where the tumor is found inside the bones and is considered the rarest form of the disease6.

Although they can occur in any age group and, as much as I have no fondness for genre, the schwannomas occur more frequently patients between the second and fifth decades of life, presenting a slight preference for the female gender, with a ratio of 1.6:1 when compared to male1.


Male patient with 63 years, sought dental office complaining about the appearance of a nodular lesion on the lower lip. Patient ex-smoker and hypertension using Somalgin Cardio, Olmetec HCT and Amlodipine Besylate, denied other comorbidities, medications and allergies.

The examination showed firm nodule, smooth surface, color similar to mucosa, painless, no bleeding, measuring in your greatest extent 1 cm in midline region of the lower lip (Figure 1). The patient denied history of trauma in the region, didn't know inform with accuracy the time of injury evolution, only that it showed slow growth. An incisional biopsy was then held and the pathological result of neuroma in encapsulated palisade was obtained (Figure 2).

Figure 1. Presence of lump in the midline region of the lower lip.

Figure 2. Photomicrograph showing injury default Antoni A the showing beams arranged and acellular areas.

In a second surgical time, excisional biopsy was performed in lower lip. The procedure was performed under local anesthesia and consisted of a large wedgeshaped incision, which was sutured with Mononylon 4.0 using sutures in the region of skin and mucosa region in points and lip with Vicryl 4.0 (Figure 3). The lump was removed, because it was wrapped, which made it easy to your removal (Figure 4).

Figure 3. Perioperative image during excision of the lesion. Suture for tissue approximation after excision of the lesion.

Figure 4. Image showing the encapsulated lump.

The final diagnosis was schwannoma. The patient is well, without motor and sensory deficit in the lower lip. Follow up of ten months ago and, so far, no sign of recurrence of injury (Figure 5).

Figure 5. Ten months after lesion removal, with no signs of recurrence.


The schwannomas are benign neoplasms, encapsulated, they receive also the nomenclature of Neurilemmoma7. Prasanna Kumar et al.1 added two more names as synonyms of the injury, being called neurinoma and perineural fibroblastoma. In your vast majority, the schwannomas do not cause damage to the neurological structures and have a predilection for the peripheral region of the cranial nerves, except the pairs I and II, since these are absent of Schwann cells3,7.

This neural tumor is usually asymptomatic and may appear at any age, however, is found between the second and third decades of life1. Raikwar et al.8 verified in their study that the age range is wider and the peak incidence varies between the third and sixth decades. On the other hand, Bhalerao et al.9 stated that the schwannoma can occur in any age group, however, when present in the oral cavity, the adults are more committed to the children. Which corroborates the present study.

According to Rathore et al.10, sites of involvement are, respectively, jugal mucosa tongue, soft palate, gums and lips. Bhalerao et al.9 cited also the involvement of the buccal floor, salivary glands and mental nerve region. The present study shows the involvement of the lower lip, which makes the schwannoma in this region a rare benign neoplasm, once the lip is made up of connective tissue, fat and skin, as well as blood vessels, nerves and salivary glands, soon, the lesions most commonly found in this region are fibroma, fibrous inflammatory hyperplasia, tumors of the salivary glands and mucocele11.

Although some authors suggest that the local trauma can be the triggering agent of injury, the etiology is still considered unknown3,4. There's a slight predilection for female gender1,9. In our study the affected patient is male. Intraosseous schwannomas are even more rare when compared to those that occur in the oral cavity. The posterior region of the mandible, being the intraosseous route of the inferior alveolar nerve, is the site of prevalence12. Gadipudi et al.12 showed that the radiographically neurilemmomas may show a wide variation of unilocular radiolucency for multilocular, with clearly defined limits and cortical bone expansion.

Clinically, the neural tumor presents as a solitary mass, of slow growth, smooth surface, usually asymptomatic. On palpation, the schwannoma can range from floating to solid cyst5. In the present work, the lesion was solid and with evolution time of slow growth. According to Laviv et al.13, schwannoma has a very characteristic histological pattern and your degree of cellularity is divided into two patterns: Antoni A and Antoni B. 1 presents the default cell organized in the form of Palisade; While the second type, the cells are disorganized in a myxoid tissue5,7,13.

Schwannomas in the head and neck region constitute approximately 25% of the extracranial tumors being the vagus nerve and the cervical sympathetic chain places of greatest involvement. However only 1% presents intraoral source. The tumor can occur in peripheral or intracranial nerves. These, when involved, have greater predilection to occur along the acoustic nerve5,8.

The differential diagnosis must be established with schwannoma in neurofibroma, lipoma, hemangioma, granuloma, leiomyoma and linfagioma14. When the tumor occurs in the lip, fibroma, fibrous inflammatory hyperplasia and mucocele are also part of the differential diagnosis11. In this study, were established, lipoma, fibroma and fibrous inflammatory hyperplasia, mucocele as diagnostic hypotheses.

The treatment of choice is given by surgical excision and, when the tumor is not in the form required an encapsulated margin of normal tissue and careful separation of the nerve involved for preservation even function14,15. The immunohistochemical analysis can complement the diagnosis, being positive marking for S-100 protein16. When performed the surgical excision of correct form, the prognosis is favorable, there is no relapse14-16. In the present work, the patient is well with no signs of injury recurrence. The malignant transformation is rare, although some cases have been reported in the literature15,16.


The schwannoma is a benign tumor that originates from the Schwann cells of the peripheral nerves. Occur infrequently in the oral cavity, being rare when they involve the lips. Despite the literature present a discrete predilection for female gender, men can also be affected. It's a tumor with low potential for malignant transformation, whose surgical excision is the treatment of choice. The professional must be prepared in front of the differential diagnosis and the correct treatment form, since the nerve involved should be held unharmed to preserve your function.


1. Prasanna Kumar D, Meghashri K. Schwannoma in the hard palate: A case report and review of literature. J Adv Oral Res. 2012;3:30-4.

2. Rêgo J, Ramalho S, Adónis C, Montalvão P, Veiga VG. Schwannoma maligno do palato mole: A propósito de um caso clínico. Rev Port Otorrinol Cir Cérvico-Facial. 2011;49(3):173-5.

3. Al-Alawi YSM, Kolethekkat AA, Saparamadu PAM, Al-Badaai Y. Sublingual Gland Schwannoma: A rare case at na unusual site. Oman Med J. 2014;29 doi: 10.5001/omj.2014.41.

4. Soares PBN, Marangon LD, Leal RM, Capistrano HM, Marigo HA. Neurilemoma: relato de caso clínico. Rev Odontol Bras Central. 2012;21:458-61.

5. Bayindir T, Kalcioglu MT, Cicek MT, Karadag N, Karaman A. Schwannoma with an uncommon upper lip location and literature review. Case Rep Otolaryngol. 2013;2013:363049.

6. Meundi MA, Anekar J, Raj AC, Patil US, Mustafa SM. Intraosseous schwannoma of the maxilla mimicking a periapical lesion: a diagnostic challenge. J Clin Diag Res. 2015;9:ZD01-4.

7. Altun S, Altun AY. Schwannoma of the lower lip, a rare entity: Case report. F Ü Sağ Bil Tıp Derg. 2013;27:145-7.

8. Raikwar KR, Ghodke M, Deshmukh V, Garde JB, Suryavanshi RK. Schwannoma for the lower lip mucosa: An unexpected finding. Ser Dent J. 2014;61:157-61.

9. Bhalerao S, Chhabra R, Tamgadge A, Tamgadge S. Cellular schwannoma of oral cavity: A case report. Int J Oral Maxillofac Pathol. 2012;3:22-5.

10. Rathore AS, Srivastava D, Narwal N, Shetty DC. Neurilemmoma of Retromolar Region in the Oral Cavity. Case Rep Dent. 2015;2015:320830.

11. Curra M, Sant'Ana Filho MS, Martins MAT, Romanini J, Carrard VC, Martins MD. Schwannoma of the upper lip: a 66-year single-center retrospective analysis in southern Brazilian population and literature cases review. J Oral Diag. 2016;01e4:53-6.

12. Gadipudi S, Sumalatha MN. Intra osseous schwannoma: A case report. J Pierre Fauchard Acad. 2012;26:22-5.

13. Laviv A, Fachin WC, August M. Schwannoma (neurilemmoma) in the floor of the mouth: Presentation of two cases. J Oral Maxillofac Surg Med Pathol. 2015;27:199-203.

14. Özgür A, Bedir R, Coşkun ZO, Erdivanli OÇ, Terzi S, Dursun E. Schwannoma of the upper lip: Case report. J Oral Maxillofac Surg Med Pathol. 2015;27:843-45.

15. Kamath MP, Kini H, Shenoy SV, Deviprasad D, Prakash N, Pai R. Schwannoma of the base tongue: A rare presentation. Egypt J Ear Nose Throat Allied Sci. 2014;15:61-4.

16. Tsushima F, Sawai T, Kayamori K, Okada N, Omura K. Schwannoma in the floor of the mouth: A case report and clinicopathological studies of 10 cases in the oral region. J Oral Maxillofac Surg Med Pathol. 2012;24:175-9.


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